Xenole 375 | Esomeprazole Magnesium 20mg + Naproxen Sodium 375mg | ePharma
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Xenole 375mg Tablet 10pcs

Generic: Esomeprazole + Naproxen

Type: Tablet

Pack Size: 10 Pcs

Esomeprazole 20 mg + Naproxen 375 mg Tablet is used for pain relief.


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Discount Price: ৳ 122.2
MRP: ৳ 130 6% Off

⪼ Save  ৳: 7.8  in this Product


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✅ Description:

Xenole 375mg Tablet is a Non-Steroidal Anti-Inflammatory Drug (NSAID) used to reduce and relieve pain. It combines Naproxen, a painkiller, and esomeprazole, an antacid. Naproxen works by blocking the COX enzyme to reduce pain and inflammation, while esomeprazole reduces stomach acid to prevent gastric discomfort and ulcers caused by Naproxen.

Take Xenole 375mg Tablet as prescribed by your doctor. Common side effects include indigestion, stomach pain, constipation, dizziness, nausea, and diarrhea, which typically resolve over time. Consult your doctor if side effects persist or worsen.

Inform your doctor if you are allergic to Naproxen, esomeprazole, other NSAIDs, or medications. If you are pregnant or breastfeeding, inform your doctor before taking Xenole 375mg Tablet. Patients over 65, or those with heart, gastrointestinal, respiratory, liver, kidney diseases, or bleeding disorders should use this medication only as prescribed. Keep your doctor informed about your health condition and all medications you take to avoid side effects.

Safety Advices


Alcohol
UNSAFE

It is unsafe to consume alcohol with Xenole 375mg Tablet.


Pregnancy
CONSULT YOUR DOCTOR

Xenole 375mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.


Breastfeeding
CONSULT YOUR DOCTOR

Xenole 375mg Tablet is safe to use during breastfeeding. Human studies suggest that the drug does not pass into breast milk in a significant amount and is not harmful to the baby.


Driving
CAUTION

Xenole 375mg Tablet may cause side effects that could affect your ability to drive. It may make you feel dizzy, depressed, sleepy, tired, or make it difficult to sleep. It may also affect your vision, which can impact your driving ability.


Kidney
SAFE IF PRESCRIBED

Xenole 375mg Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed. Please consult your doctor.


Liver
SAFE IF PRESCRIBED

Xenole 375mg Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed. Please consult your doctor.

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✔️ Uses of Xenole 375mg Tablet

Treatment of Pain

✔️ How does Xenole 375mg Tablet work?

Xenole 375mg Tablet is a combination of two medicines: Naproxen and Esomeprazole which relieve pain. 

  • Naproxen is a non-steroidal anti-inflammatory drug (NSAID) that works by blocking the release of certain chemical messengers that cause fever, pain, and inflammation (redness and swelling).
  • Esomeprazole is a proton pump inhibitor. which reduces the amount of acid in the stomach and prevents damage to the stomach lining caused by Naproxen.
✔️ Side Effects of Xenole 375mg Tablet

Esomeprazole reduces gastrointestinal side effects from naproxen. This combination significantly decreases the occurrence of gastric ulcers and NSAID-associated upper GI adverse events compared to naproxen alone. Common side effects include gastrointestinal issues like nausea, vomiting, diarrhea, and abdominal pain. Serious but rare side effects include peptic ulcers, GI bleeding, hypertension, and cardiac failure.

✔️ Quick Suggestions:
  • Physical activity helps strengthen muscles and relieve joint stiffness. Gentle activities like 20-30 minutes of walking or swimming are beneficial. Yoga can also improve joint flexibility and pain management.
  • Maintaining a healthy weight through regular low-strain exercises and a healthy diet is important. Ensure adequate sleep to help reduce muscle inflammation and swelling.
  • Using heat or cold therapy, such as applying a hot or cold compress to joints for 15-20 minutes regularly, can be helpful. Acupuncture, massage, and physical therapy may also provide relief.
  • Inform your doctor if you are elderly, a smoker, have had a stroke, or have high blood pressure, diabetes, or high cholesterol, as these conditions may increase the risk of heart problems. Long-term use of Xenole 375mg Tablet may require monitoring of liver and kidney function. Those at risk for osteoporosis-related fractures should ensure adequate calcium and vitamin D intake.
  • Esomeprazole in Xenole 375mg Tablet can interfere with certain lab tests, potentially causing false results. Inform lab personnel and doctors about your use of this medication. Regular monitoring of vitamin B-12 levels is advised, as long-term use of esomeprazole can lead to a deficiency.
✔️ Naproxen & Esomeprazole is prescribed for:
  • Relief of symptoms of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis
  • Reducing the risk of developing gastric ulcers in patients prone to NSAID-associated gastric ulcers.
✔️ Pharmacology

Xenole 375mg Tablet consists of an immediate-release esomeprazole magnesium layer and an enteric-coated naproxen core. Esomeprazole is released first into the stomach, followed by naproxen in the small intestine.

Naproxen is an NSAID with analgesic and antipyretic properties that inhibits prostaglandin synthesis. Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by inhibiting the H+/K+-ATPase in gastric parietal cells, thereby reducing gastric acidity.

✔️ Dosage & Administration of Xenole 375mg Tablet

Carefully weigh the benefits and risks before deciding to use this medication. Use the lowest effective dose for the shortest duration consistent with individual treatment goals. If a total daily dose of esomeprazole lower than 40 mg is needed, consider a different treatment.

  • Rheumatoid Arthritis, Osteoarthritis, and Ankylosing Spondylitis (Adults): One tablet twice daily (either 375 mg naproxen/20 mg esomeprazole or 500 mg naproxen/20 mg esomeprazole).
  • Juvenile Idiopathic Arthritis (Adolescents 12 years and older):
    • Weight >50 kg: One tablet twice daily (either 375 mg naproxen/20 mg esomeprazole or 500 mg naproxen/20 mg esomeprazole).
    • Weight 38-50 kg: One tablet twice daily of 375 mg naproxen/20 mg esomeprazole.

Administration

Do not split, chew, crush, or dissolve the tablet. Take at least 30 minutes before meals.

✔️ Interaction

With other medications:

  • NSAIDs may reduce the antihypertensive effect of ACE inhibitors, diuretics, and beta-blockers.
  • Concomitant use of warfarin may increase the risk of bleeding complications.
  • Esomeprazole may interfere with the absorption of drugs where gastric pH is important for bioavailability (e.g., ketoconazole, iron salts, digoxin).

With food:

  • High-fat food does not affect naproxen absorption but prolongs tmax by 10 hours and decreases Cmax by about 12%.
✔️ Contraindications
  • Known hypersensitivity to any component of this medication or substituted benzimidazoles.
  • History of asthma, urticaria, or other allergic reactions after taking aspirin or other NSAIDs.
  • Use during the peri-operative period for coronary artery bypass graft (CABG) surgery.
✔️ Pregnancy & Lactation
  • Pregnancy: Avoid unless the benefits outweigh the risks, especially during the first and second trimesters. Contraindicated during the third trimester.
  • Breastfeeding: Naproxen is excreted in low quantities in breast milk. It is unknown if esomeprazole is excreted. Avoid use during breastfeeding.
  • Fertility: NSAIDs like naproxen may impair female fertility. Not recommended for women attempting to conceive.
✔️ Precautions & Warnings
  • General: Avoid combining with other NSAIDs, including selective cyclooxygenase-2 inhibitors, due to cumulative risks. Can be used with low-dose aspirin.
  • Elderly: Higher risk of adverse reactions, particularly gastrointestinal bleeding and perforation.
  • Gastrointestinal: Risk of GI bleeding, ulceration, or perforation increases with NSAIDs. Use with caution in patients with a history of GI disease.
  • Cardiovascular and Cerebrovascular: Monitor patients with hypertension, heart failure, or cardiovascular disease closely.
  • Renal: Long-term use can cause renal injury. Not recommended for moderate to severe renal impairment.
  • Hepatic: Monitor patients with mild to moderate hepatic impairment closely. Not recommended for severe hepatic impairment.
✔️ Storage Conditions:

Store below 30°C, protected from light and moisture. Keep out of reach of children.

Frequently Asked Questions (FAQ)

Naproxen overdose: Symptoms include lethargy, dizziness, drowsiness, epigastric pain, and GI bleeding. Manage with symptomatic and supportive care. Hemodialysis is not effective due to high protein binding. Esomeprazole overdose: Symptoms are usually transient. No specific antidote; manage with supportive care.

Xenole 375mg TabletT may inhibit ovulation and decrease progesterone levels, potentially leading to temporary infertility in women. Ovulation typically returns to normal after stopping the medication. Inform your doctor if you are planning to become pregnant or have difficulties with fertility before taking Xenole 375mg Tablet.

Naproxen in Xenole 375mg Tablet may increase the risk of heart problems such as heart attack and stroke, especially when used in high doses or for a prolonged duration. Inform your doctor if you have a history of heart problems or stroke before taking this medication. Xenole 375mg Tablet should not be used by patients who have had recent heart bypass surgery (coronary artery bypass graft - CABG).

It is not recommended to take Xenole 375mg Tablet with clopidogrel as it may increase the risk of bleeding. Consult a doctor immediately if you notice symptoms like blood in urine or stools, dizziness, unusual bleeding or bruising, vomiting, weakness, or headache. If necessary, your doctor may adjust the dose for safe use.

Xenole 375mg Tablet does not cure arthritis but relieves symptoms such as joint pain, swelling, and stiffness. Arthritis is a chronic condition, and this medication helps manage its symptoms.

Yes, Xenole 375mg Tablet can alter specific medical tests, including neuroendocrine tumor tests (secretin stimulation test) and urine screening tests for tetrahydrocannabinol (THC). Inform your doctor before undergoing such diagnostic tests.

Xenole 375mg Tablet contains Naproxen (NSAID or pain reliever) and esomeprazole (antacid). Naproxen blocks the release of chemical messengers (prostaglandins) that cause pain and inflammation. Esomeprazole inhibits the gastric proton pump, reducing acid production and healing ulcers while preventing new ones.
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Check our pricing section for Xenole 375mg Tablet 10pcs price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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